Mohammad Hasan Abdollahi, Azade Boostani, Seyyed Omid Mahdavi, Habibollah Hosseini, Seyed Hossein Hekmatimoghaddam, Ali Akbar Rahimianfar,
Both anesthesia and major surgeries may affect the immune system, especially the cell-mediated immune re-sponses, but also the humoral immunity. Our goal was to assess the effect of propofol and isoflurane on the se-rum concentration of immunoglobulins G, M, A and E in patients undergoing off-pump coronary artery bypass graft (CABG) surgery. This study was a double-blinded randomized clinical trial. Sixty patients were randomly di-vided into two equal groups receiving either isoflurane or propofol as the inhaled anesthetic agent during oper-ation. Other parts of the medical conditions, anesthesia and surgery were quite similar in two groups. Baseline serum immunoglobulins G, M, A and E in both groups were measured by enzyme immunoassay one day prior to and four days after the surgery. Data were analyzed by the SPSS ver. 15 (SPSS, USA) using t-test, paired t-test and chi-square test. The mean serum IgG (p=0.378), IgM (p=0.593), IgA (p=0.095) and IgE (p=0.404) did not differ significantly between the isoflurane group and propofol group before the surgery. Serum immunoglobulins were significantly decreased after the surgery. However, the means of IgG (p=0.452), IgM (p=0.239), IgA (p=0.153) and IgE (p=0.482) did not show any significant difference between the two groups. In patients who undergo off-pump CABG surgery, both isoflurane and propofol cause decrease in serum IgG, IgM, IgA and IgE; however, there is no significant difference between them regarding the amount of this fall. "