Nicolas Xiao
For many biological processes in mammals, iron is a crucial transition metal. Several coordination mechanisms, including as absorption, utilization, recycling, and storage, are used to control iron metabolism. As a result of intracellular iron retention brought on by iron dyshomeostasis, free oxygen radicals can harm cells, tissues, and organs. Brain iron excess has been linked to the pathogenic process of neurodegenerative diseases, including Alzheimer's Disease (AD), according to a number of studies. The fundamental mechanisms, nevertheless, are still not completely understood. We may gain a fresh perspective from ferroptosis, a newly identified irondependent form of cell death that is unique from apoptosis, necrosis, autophagy, and other types of cell death. Here, we want to review the state of our understanding of iron metabolism.