Hassan MB, Hammam NA, Fuad AR, Bakr HA and Abdulrhman Ahmed G
SCD is one of the major health problems in Saudi Arabia, especially in Southern, Western and Eastern areas where the gene frequency of this disease is quite prevalent. Many studies were carried out in these areas. There is a lack of studies of the effect of consanguinity on disease outcome and prognosis. We did this study in western area in Almadinah Almunawarah. We determined the effect of consanguinity on the disease by three factors. These factors are (Blood Transfusion, First complain and complications). In this study, we carried out a retrograde analysis of patients’ files, and found that 44% of the patients were products of consanguineous marriages. But the research concluded that there was no clear increase in complications caused by the state of consanguinity of the patient’s parents, although patients on consanguineous parents have had slightly more incidences of vaso-oclusive crisis.