Maria Carolina Fra, Mattia Cason, Elmor Moore, Luca Cristani, Tommaso Maluta and Massimo Corain
Objective: Trapeziometacarpal Joint Osteoarthritis (TMJOA) is the second most common degenerative disease of the hand after interphalangeal joint osteoarthtritis. This condition is influenced by aging and comorbidities determining an increase in pharmacological treatment and a high social and economic burden. Natural substances such as Hyaluronic Acid (HA), Chondroitin Sulfate (CS), and glucosamine are starting to be used as ground therapy to reduce the consumption of NSAIDs and their adverse events. Ialòral® 1500 is a natural compound made of biocell collagen, cynantine, manganese, and bioperine. Our objective was to evaluate the effect of a 1-month therapy with Ialòral® 1500 through DASH score and to consider if this treatment leads to pain reduction (NRS score) and strength improvement (Jamar test and Pinch test).
Design: In 3 months, we recruited through X-Ray (XR), Jamar test; Pinch test, NRS, and DASH score 40 patients with TMJOA. Patients assumed once a day for 28 days an oral supplement of 120 mg HA, 240 mg CS, 300 mg K, keratin matrix, manganese, and piperine. NRS and DASH score were assessed at 2, 4, 8 weeks from the beginning (T1, T2, T3) whereas Jamar and Pinch tests were done during T2 and T3 visits.
Results: Our study showed improvement in DASH, NRS scores and in the grip and pincher movements. Results were more significant for the advanced stages.
Conclusion: This oral supplementation may provide an additional non-invasive possibility of treatment of the of TMJOA symptoms, especially for those patients with contraindication to more invasive approaches.