जर्नल ऑफ फार्मास्युटिकल साइंसेज एंड ड्रग डेवलपमेंट

THE INFLUENCE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (eNOS) GENETIC POLYMORPHISMS ON CHOLESTEROL BLOOD LEVELS AMONG DIABETIC PATIENTS TYPE II ON AATORVASTATIN THERAPY

Yazun Jarrar

ABACKGROUND: Endothelial nitric oxide synthase
(eNOS) plays a major role in the response of anti-hypercholesterol
statin drugs. Genetic polymorphisms in
eNOS gene affect eNOS’s activity and hence modulate
statins response.
OBJECTIVES: This study investigated the influence of
major functional eNOS gene polymorphisms (rs2070744,
rs1799983 and rs61722009) on the lipid profile of diabetes
mellitus type 2 (T2DM) Jordanian patients on atorvastatin
treatment.